Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans.
نویسندگان
چکیده
BACKGROUND AND PURPOSE Genetic variation in the EPHX2 gene region has been reported to influence susceptibility to ischemic stroke in blacks. We assessed the role of this gene region in white Europeans and performed analyses with regard to stroke subtypes. METHODS Twenty-six single nucleotide polymorphisms in the EPHX2 gene region were genotyped in 601 patients with ischemic stroke and 736 matched controls. Cases were subtyped according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification system. Analyses were done on single markers and haplotypes using a sliding-window approach. RESULTS Three single nucleotide polymorphisms showed associations with an increased risk for ischemic stroke (allelic models; all P<or=0.01). One of them retained statistical significance after correction for multiple testing. Associations were observed with large-vessel stroke and stroke of undetermined etiology but not with other stroke subtypes. CONCLUSIONS Our findings confirm and extend previous studies suggesting that genetic variation in or near the EPHX2 gene contributes to the risk of ischemic stroke. This association seems to be mediated predominantly by large-vessel disease.
منابع مشابه
The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke.
Stroke is the leading cause of severe disability and the third leading cause of death, accounting for one of every 15 deaths in the USA. We investigated the association of polymorphisms in the soluble epoxide hydrolase gene (EPHX2) with incident ischemic stroke in African-Americans and Whites. Twelve single nucleotide polymorphisms (SNPs) spanning EPHX2 were genotyped in a case-cohort sample of...
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عنوان ژورنال:
- Stroke
دوره 39 5 شماره
صفحات -
تاریخ انتشار 2008